Dear RDI subscriber / HIV-TRePS user,
Our latest study, now published online in HIV Medicine, shows that HIV-TRePS performs comparably well with, or without, a genotype and significantly outperforms genotyping as a predictor of response to treatment.
The study compared the performance of the two sets of models used to power HIV-TRePS that do, and do not, require a genotype for their predictions of response. The models predicted virological response for 99 three-drug regimens for patients on a failing regimen of two nucleoside/nucleotide reverse transcriptase inhibitors and one non-nucleoside reverse transcriptase inhibitor in the Second-Line study.
o The rankings of alternative regimens by the two sets of models were significantly correlated in the majority of cases.
o The two sets of models identified alternative regimens that were predicted to be effective in 97%-100% of cases.
o The models performed with 72% and 74% accuracy compared with 55% for genotyping with rules-based interpretation (using the Stanford database).
The paper can be viewed here:
We hope you find this of interest.
The RDI team.
Date published: 17th April 2014