Dear RDI subscriber
We have tested the current HIV-TRePS models that do not require a genotype with real clinical cases from resource-limited settings and the results are published online today in the Journal of Antimicrobial Chemotherapy. The models predicted virological response to therapy with comparable accuracy to the use of a genotype with rules-based interpretation. They were also able to identify available alternative regimens that were predicted to be effective for the great majority of failures from these clinics in Southern Africa, India and Romania. The results suggest that they could play a useful role in optimising therapy settings with limited resources.
The press release from the journal publishers, Oxford University Press, follows and the paper itself can be found here:
We hope you find the paper interesting and that you will alert your colleagues and contacts, particularly those in resource-limited settings, to the existence and potential utility of HIV-TRePS.
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The RDI team.
Date published: 13th March 2013