The current activities of the RDI can be divided into two:

1. The ongoing core activities of:

• Adding data to the database
• Exploring the relationship between changes in the genetic code of HIV (genotype) and response to HIV drug therapy
• Developing computational models for helping physicians and their patients to select the best combination of dugs for the individual.

2. Specific research projects.

1. Current status of core activity
As of January 2007, the RDI database contained data from approximately  30,000 patients. The unit of data used for modelling consists of a treatment change episode (TCE). A TCE includes all the relevant data for a patient around when s/he were started on a new antiretroviral drug therapy. The number of TCEs available for modelling is approximately 9,000.

2. Current research projects
 During 2007, the main research project will be a multicentre, international clinical pilot study, involving centres in USA, Canada and Italy. During the study, physicians whose HIV patients require a change to their HIV drug therapy will have access to the RDI’s models over the Internet. Following input of key, anonymised  data from their patient, they will receive a prototype report listing possible combinations of drugs that the models predict will be effective.